Model error and uncertainty is a challenge in the wind energy industry, potentially leading to mischaracterization of millions of dollars' worth of wind resource. This paper combines meteorological knowledge with machine learning techniques, specifically artificial neural networks (ANNs), to better extrapolate wind speeds. It is found that ANNs can reduce power-law extrapolation error by up to 52 % while simultaneously reducing uncertainty. A test case is shown to help decipher the ANN results.