Most current wind turbine wake models struggle to accurately simulate spatially variant wind conditions at a low computational cost. In this paper, we present an adaptation of NREL's FLOw Redirection and Induction in Steady State (FLORIS) wake model, which calculates wake losses in a heterogeneous flow field using local weather measurement inputs. Two validation studies are presented where the adapted model consistently outperforms previous versions of FLORIS that simulated uniform flow only.