This paper presents a study of the popular wind turbine design tool OpenFAST. We compare simulation results to measurements obtained from a 2.8 MW land-based wind turbine. Measured wind conditions were used to generate turbulent flow fields through several techniques. We show that successful validation of the tool is not strongly dependent on the inflow generation technique used for mean quantities of interest. The type of inflow assimilation method has a larger effect on fatigue quantities.